. 2017 May 17;6(5):e005479. doi: 10.1161/JAHA.117.005479

Table 2.

Association of Each Cardiometabolic Component, Their Clustering, and MetS With All‐Cause and Cardiovascular/Cerebrovascular Mortality

	All‐Cause		CVD/CBV
	HR (95% CI)	P Value	HR (95% CI)	P Value
No. of deaths	348		147
Individual components
Obesity	1.15 (0.91–1.45)^a	0.25	1.32 (0.90–1.93)^a	0.16
Hypercholesterolemia	0.87 (0.69–1.10)^a	0.22	1.22 (0.86–1.70)^a	0.26
Hypertriglyceridemia	1.11 (0.89–1.38)^a	0.37	1.12 (0.79–1.52)^a	0.52
Glucose dysregulation	1.38 (1.10–1.76)^a	<0.01^b	1.18 (0.83–1.70)^a	0.34
High blood pressure	1.43 (1.12–1.84)^a	<0.01^b	1.51 (1.01–2.29)^a	0.05^b
Cumulative no. of components
0	1.00		1.00
1	0.96 (0.62–1.50)	0.87	0.53 (0.25–1.15)	0.11
2	0.90 (0.59–1.37)	0.59	0.70 (0.36–1.37)	0.29
3	1.75 (1.18–2.61)	<0.01^b	1.27 (0.66–2.42)	0.47
4	1.79 (1.01–3.20)	0.05^b	1.51 (0.78–2.94)	0.22
5	2.24 (1.32–3.79)	<0.01^b	1.78 (0.74–4.29)	0.20
MetS
No (<3 components)	1.00
Yes (≥3 components)	1.73 (1.40–2.14)^c ^, ^d	<0.01^b	1.92 (1.35–2.74)^c	<0.01^b

CBV indicates cerebrovascular; CVD, cardiovascular disease; HR, hazard ratio; MetS, metabolic syndrome; SDB, sleep disordered breathing.

Hazard ratios (95% CIs) adjusted for one another as well as for age, race, sex, smoking, alcohol use, depression, insomnia, SDB, heart disease, stroke, and objective sleep duration.

P<0.05.

Hazard ratios (95% CIs) adjusted for age, race, sex, smoking, depression, insomnia, SDB, heart disease, stroke, and objective sleep duration.

P value for MetS×objective sleep duration interaction <0.05. All data adjusted by sampling weight. Obesity=body mass index ≥30 m²/kg. Hypercholesterolemia=elevated total cholesterol levels (≥200 mg/dL). Hypertriglyceridemia=elevated triglycerides levels (≥150 mg/dL). Glucose dysregulation=elevated fasting glucose levels (≥100 mg/dL) or treatment for diabetes mellitus. High blood pressure=elevated blood pressure levels (≥130/85 mm Hg) or antihypertensive treatment.