Table 3.
CMR Results
| 7 Days Post‐AMI | 60 Days Post‐AMI | |||||
|---|---|---|---|---|---|---|
| Vehicle (n=7) | ATMSCs (n=7) | P Value | Vehicle (n=7) | ATMSCs (n=7) | P Value | |
| LVEDV, mL | 133.2±17.0 | 133.4±22.6 | 0.986 | 201.3±37.3 | 190. 6±37.2 | 0.600 |
| LVESV, mL | 80.3±16.9 | 74.3±15.9 | 0.510 | 126.5±35.8 | 110.6±30.4 | 0.387 |
| LVEF, % | 40.2±5.2 | 44.4±3.6 | 0.110 | 37.9±6.3 | 42.7±5.2 | 0.142 |
| Infarct size (% LV) | 30.8±5.5 | 25.0±5.0 | 0.061 | 19.1±4.3 | 15.4±4.7 | 0.153 |
| MVO (% infarct) | 6.2±7.2 | 6.0±8.1 | 0.960 | — | — | — |
| Edema (% LV) | 32.1±5.4 | 26.3±4.9 | 0.059 | — | — | — |
| Infarct size (% edema) | 0.96±0.04 | 0.95±0.06 | 1.000 | — | — | — |
| Myocardial perfusion, mL/min per gram | ||||||
| Core infarcted area | 52.7±35.0 | 45.6±22.9 | 0.658 | 64.5±16.7 | 69.8±19.6 | 0.618 |
| Anterior infarct border | 57.4±17.7 | 87.9±28.7 | 0.034 | 43.3±14.7 | 99.0±22.6 | <0.001 |
| Septum infarct border | 65.5±26.6 | 71.9±14.8 | 0.588 | 60.6±3.7 | 76.2±30.1 | 0.237 |
| Posterior remote wall | 214.3±73.3 | 212.5±76.8 | 0.965 | 120.2±3.7 | 179.3±87.5 | 0.118 |
Values are represented as mean±SD. Edema sequences and MVO were only available at the 7‐day CMR study.18 AMI indicates acute myocardial infarction; ATMSCs, adipose tissue‐derived mesenchymal stem cells; CMR, cardiac magnetic resonance imaging; LV, left ventricle; LVEDV, left ventricular end‐diastolic volume; LVEF, left ventricular ejection fraction; LVESV, left ventricular end‐systolic volume; MVO, microvascular obstruction.