Table.

Ongoing studies examining diagnostic approaches to idiopathic pulmonary fibrosis

	Study location	Primary goals
General
NCT01915511	Boehringer Ingelheim and Duke University	Define natural IPF history; define data on current practice patterns for IPF diagnosis; define the effect of IPF on quality of life; bank blood samples
NCT02772549	University Hospital, Gentofte, Copenhagen	Define the diagnostic delay before an IPF diagnosis is made
NCT02479126	Durham VA Medical Center and Boehringer Ingelheim	Define the prevalence of ILD in the VISN6 VA patient population; define the prevalence of IPF in theVISN6VA patient population; establish the accuracy of ICD-9 codes for diagnosis of ILD; compare the reported ICD-9 code diagnosis with the diagnosis made after chart review and re-interpretation of lung imaging and pathology; record the frequency of ICD-9 code diagnosis of ILD and clinic consultation with a pulmonary provider; define the prevalence of comorbid diabetes mellitus with ILD; compare the prevalence of diabetes with ILD as compared with the prevalence of diabetes in the general VA population
NCT00540475	University of Pittsburgh, Temple University, University of Pennsylvania, Geisinger Clinic, and Milton S. Hershey Medical Center	Assess the extent of lung fibrosis in Pennsylvania; provide better access to standard of care and diagnosis of patients with pulmonary fibrosis in all regions of Pennsylvania; facilitate the translation of new therapeutic interventions from the bench to the bedside
Lung sampling techniques
NCT01714518	Wissenschaftliches Institut Bethanien e.V	Assess the efficiency and safety of cryobiopsy compared with VATS in diagnosis of ILD
NCT02563730	University Hospital Tuebingen	Clarify whether the addition of cryobiopsy can avoid surgical lung biopsy in a clinically relevant proportion of patients with suspected idiopathic interstitial pneumonia
NCT02235779	Laval University	Evaluate the diagnostic yield, feasibility, and safety of transbronchial lung cryobiopsies done via bronchoscopy in the investigation of interstitial lung disease in comparison with VATS
NCT02075762;NCT01972685	Johns Hopkins University and Duke University	Compare the sample size, architectural preservation, and diagnostic yield of bronchoscopic cryoprobe transbronchial lung biopsy, in comparison with bronchoscopic standard transbronchial lung biopsy and VATS lung biopsy for the diagnosis of ILD
NCT02579304	Katholieke Universiteit Leuven	Evaluate the diagnostic value of transbronchial lung cryobiopsy and its procedural feasibility and safety in a prospective series of 20 patients with ILD who are referred for invasive histopathological diagnostic testing
NCT02763540	University Hospital, Montpellier	Compare the pathological features of surgical open lung biopsies and cryobiopsies in non-1 PF ILD. Patients with non-1 PF ILD who are eligible for an open lung biopsy will undergo cryobiopsy at the same time. Interobserver agreement will be assessed for each pair of samples
ACTRN12615000718549	Multiple centres	Validate transbronchial lung cryobiopsy against VATS biopsy in the diagnosis of ILD
Physiological techniques
NCT02827734	Universitätsmedizin Mannheim	Define lung clearance and airway resistance in various ILDs
Imaging techniques
NCT01624753	Singapore General Hospital	Explore the value of fibered confocal fluorescence microscopy in providing diagnostic information on fibrosis and inflammation of the distal air spaces associated with ILD without the need for lung biopsies; identify and catalogue distinct and discriminating features seen on images obtained from fibered confocal fluorescence microscopy, and correlate these findings with specific high-resolution CT features and pathological findings if available; create diagnostic criteria for fibered confocal fluorescence microscopy image interpretation of specific ILDs
Molecular markers
NCT00632307	Lung Clinic Hemer	Define disease-specific clusters of volatile organic compounds in patients with different lung diseases, including ILD, using breath analysis with ion mobility spectrometry
NCT00258544	University of Pittsburgh	Identify unique genetic markers in scarred lung that could ultimately lead to new approaches to the diagnosis and treatment of pulmonary fibrosis
N/A	Multiple centres	BRAVE-3 (Bronchial Sample Collection for a Novel Genomic Test)—to collect transbronchial biopsy specimens, clinical data, and pathology slides for external review to optimise a molecular profiling diagnostic test in patients with ILD

IPF=idiopathic pulmonary fibrosis. ILD=interstitial lung disease. VA=Veterans Affairs. VATS=video-assisted thoracoscopic lung biopsy.