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Native MS and IM-MS for benchmarking bioconjugation strategies. (a-c) Deconvoluted native mass spectra from the Orbitrap showing drug load profiles (left panels) and native IM-MS plots of m/z vs. drift time from the Q-TOF instrument for brentuximab vedotin (a), trastuzumab emtansine (b) and CBW-03–106 DAR4 site-specific ADC (c).
