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Transcytosis of different 3H-labeled IgG Fc mutants and non-binding control (chicken IgY) at pH 6.0/8.0 in human FcRn MDCK cells and EV MDCK cells as negative control. AAA, Wt, and YTE IgG clearly differed by their flux (Papp). Paired t-test P value (AAA vs. Wt IgG) = 0.024; P value (YTE vs. Wt IgG) = 0.041; P value (AAA vs. YTE IgG) = 0.002; Data is shown as mean ± SD; n = 3 (separate wells).
