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. 2017 Apr 25;9(5):781–791. doi: 10.1080/19420862.2017.1320008

Figure 6.

Figure 6.

(A) Correlation of reciprocal Wt IgG-normalized in vitro flux (pH gradient 6.0/7.4) of 7 mAbs across human FcRn MDCK cells with in vivo clearance in cynomolgus monkey. Data is plotted as mean values  ±  SD. Corresponding pairs of Fc mutant and Wt IgG are labeled with the same symbol (closed triangle, star, cross). The greyish area roughly indicates mAbs for which in vivo CL is hypothesized to be affected by “decelerating” processes, for mAbs in the white area “CL-accelerating” processes are thought to be involved. (B) Correlation of reciprocal Wt IgG-normalized in vitro flux (pH gradient 6.0/7.4) of 20 mAbs with wildtype FcRn binding ability across human FcRn MDCK cells with in vivo clearance in cynomolgus monkey. Data is plotted as mean values  ±  SD for CL and as reciprocal mean values of the Wt IgG-NF. The greyish area roughly indicates mAbs for which in vivo CL is hypothesized to be affected by “decelerating” processes, for mAbs in the white area “CL-accelerating” processes are thought to be involved.