Table 5.

In vivo studies for anti-DLL4 Fab’2 fragment.

Species	Study	Dose/s	Group sex and size	Findings
Sprague Dawley rat	8 week GLP toxicology	0 mg/kg (iv)	10M+10F/group and 5M+5F recovery/group and 6M+6F TK satellites/group	Liver findings: Decreased severity compared with IgG, minimal changes observed at low doses (up to 10 mg/kg)
		3 mg/kg (iv)		Acceptable hematology profile
		10 mg/kg (iv)		Proliferative vascular neoplasms not observed
		100 mg/kg (iv)		New findings: Vascular proliferative/degenerative changes in the heart and lung potentially related to pulmonary hypertension
		30 mg/kg (iv)
Cynomolgus monkey	8 week GLP toxicology with 12 week recovery	0 mg/kg (iv)	3M+3F/group and 2M+2F recovery/group and 2M+2F for telemetry on the control and high dose group	Liver findings: Decreased severity compared with IgG
		5 mg/kg (iv)		Acceptable hematology profile
		15 mg/kg (iv)		New findings: Vascular proliferative/degenerative changes in the heart and lung potentially related to pulmonary hypertension
		50 mg/kg (iv)