Table 3.

PK properties of IgG 3–43 after the first (day 14) and last (day 32) injection into tumor-bearing mice.

dose [µg]	injection	t½α [h]	t½β [h]	AUC0–72h [nM·h]	Cmax [nM]
30	first	11.7 ± 0.8	59.1 ± 28.4	2,365 ± 84	157 ± 35
	last	19.7 ± 4.0	87.1 ± 9.9	14,498 ± 873	480 ± 32
100	first	17.3 ± 5.3	47.8 ± 7.2	22,101 ± 5,882	717 ± 147
	last	18.7 ± 3.0	126.5 ± 10.1	62,605 ± 5,046	2,172 ± 345
300	first	32.4 ± 9.5	127.9 ± 9.6	151,558 ± 38,462	4,453 ± 1,569
	last	37.1 ± 9.4	224.2 ± 116.6	610,044 ± 137,488	22,582 ± 5,472