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. Author manuscript; available in PMC: 2017 Nov 10.
Published in final edited form as: Nature. 2017 May 10;546(7658):370–375. doi: 10.1038/nature22403

Figure 2. Locations and consequences of recurrent CNA regions.

Figure 2

(a) Genomic locations of CNAs. Colours denote the significance level of recurrence. (b) Genes differentially expressed between lines with CN 2 and 3 for the recurrent chr17 CNA. Horizontal bar denotes 1% FDR threshold (Benjamini-Hochberg). (c) Top panel shows genomic location versus number of lines with CN 3 (grey) and with a CNA (black). Bottom panel shows the NAV gene score from ref22 and log2 gene expression fold change between the iPSC lines with CN 2 and 3 (color scale), in the region highlighted in red in the top panel. Highlighted genes are up-regulated when copy number increases, known onco/tumour-suppressor genes and/or genes with NAV score in the top 2%.