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. Author manuscript; available in PMC: 2017 Sep 13.
Published in final edited form as: Nat Immunol. 2017 Mar 13;18(5):530–540. doi: 10.1038/ni.3710

Fig. 3. STAT1 and STAT6 binding in response to IFN-γ, IL-4 or co-stimulation.

Fig. 3

(a) Scatter plot showing STAT1 peaks induced by IFN-γ and not overlapping with STAT6 peaks (blue dots), and STAT6 peaks induced by IL-4 and not overlapping STAT1 (green dots). Overlapping STAT1/STAT6 peaks are represented by red dots. (b) STAT1 binding in cells stimulated with IFN-γ +/- IL-4 for 2h. (c) STAT6 binding in cells stimulated with IL-4 +/- IFN-γ for 2h. (d) Density plot showing the overall effects of the co-stimulation on STAT1 (blue) or STAT6 (green) genomic binding induced by IFN-γ or IL-4. (e) Representative snapshots showing binding of STAT6 and STAT1 and H3K27Ac signals after single or combined stimulation at cross-regulated genomic loci.