Table 2.
Association of weighted genetic risk scores (GRSs) of GWAS-identified CRC risk variants with CRC risk in Asians.
| GRS Quintilesa | Overall GRSb | Asian-specific GRSc | ||||||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| Controls (N = 3,553) | Cases (N = 3,303) | OR | 95% CI | Controls (N = 3,553) | Cases (N = 3,303) | OR | 95% CI | |
| Q1(low) | 711 | 460 | 1.00 | reference | 711 | 477 | 1.00 | reference |
| Q2 | 711 | 563 | 1.25 | 0.99–1.59 | 711 | 573 | 1.15 | 0.91–1.46 |
| Q3 | 709 | 678 | 1.47 | 1.17–1.86 | 709 | 631 | 1.41 | 1.12–1.78 |
| Q4 | 712 | 697 | 1.76 | 1.40–2.22 | 712 | 677 | 1.37 | 1.09–1.72 |
| Q5 | 710 | 905 | 2.00 | 1.60–2.50 | 710 | 945 | 2.05 | 1.65–2.56 |
| P for trend | 1.24×10−13 | 3.02×10−14 | ||||||
Adjusted for age, sex, study, and the global genomic principal components.
a
Quintile cut-points for (1) Overall GRS: Q1≤4.14, Q2: 4.15 to 4.45, Q3: 4.46 to 4.72, Q4: 4.73 to 5.02, Q5≥5.03; and (2) Asian-specific GRS: Q1≤ 2.57, Q2: 2.58–2.79, Q3: 2.80 to 2.99, Q4: 3.00 to 3.21, Q5≥3.22.
b
Overall GRS was constructed using all CRC risk variants identified to date and available to this study.
c
Asian-specific GRS was constructed using CRC risk variants identified or replicated in Asian populations to date and available to this study.