Fig. 10.

Effects of L-Cysteine on brain atrophy and behavior changes in the open field test at 14 days following HI insult. (A) Representative brain photos of mice were taken14 days after HI insult. Note the brain asymmetry and atrophy in the ipsilateral hemisphere after HI. Treatment with L-Cysteine after HI (HI + L-Cys) prevented the atrophy; however, a small degree of asymmetry was still visible (lower left image). (B) Nissl staining of the brain was performed 14 days after HI insult. (C) The quantification of tissue loss was expressed as (contralateral area−ipsilateral area/contralateral area) × 100. Values representthe mean ± SD, n = 6 in each group. (D) The locomotion was measured using an open field test, n=10 in each group. Values represent the mean ± SD, **p < 0.01, ***p < 0.001 HI VS Sham; #p < 0.05, ##p < 0.01 HI + L-Cys VS HI; && p < 0.01, &&& p < 0.001 HI + L-Cys + AOAA VS HI + L-Cys.