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. 2017 Jul 20;13:1744806917719847. doi: 10.1177/1744806917719847

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 7. — NMDA receptor-mediated puff-application of Glu evoked Ca²⁺ signal in spine of ACC pyramidal neurons. (a) Far left, two-photon fluorescent image of a dendritic segment containing active spines. The yellow dashed circles indicate the position of the frame scan. Right, four spines representative calcium transients waveforms of fluorescence changes (ΔF/F) in response to puff-application of 1 mM Glu (10 psi, 100 ms) in the control, CNQX, and CNQX + AP5 conditions, respectively. (b) Average traces of Ca²⁺ signals (ΔF/F) in responsive spines evoked by puff-application of Glu in the control ACSF, presence of CNQX (20 µM), and AP5 (50 µM), respectively. (c) Pie graph showing the percentage of active spines in the puff-application of Glu. (d) Summary results showing the percentage of Ca²⁺signals (ΔF/F) in responsive spines in the presence of CNQX and AP5. *P < 0.05, error bars indicated SEM. The amplitudes of Ca²⁺ signals (ΔF/F) were normalized to control values.