Table 4. Summary of differential abundance analysis between late-onset preeclampsia and normal pregnancy in five intervals of gestation.
| 8–16 (weeks) | 16.1–22 (weeks) | 22.1–28 (weeks) | 28.1–32 (weeks) | 32.1–36 (weeks) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SYMBOL | FC | Sig. | FC | Sig. | FC | Sig. | FC | Sig. | FC | Sig. |
| PPID | 1.4 | Yes | 1.4 | Yes | 1.6 | Yes | 1.3 | No | 1.1 | No |
| RAN | 1.4 | Yes | 1.4 | Yes | 1.6 | Yes | 1.5 | No | 1.1 | No |
| MMP-7 | 1.4 | Yes | 1.4 | Yes | 1.3 | Yes | 1.2 | No | 1.2 | No |
| CDK8/cyclin C | 1.2 | Yes | 1.1 | Yes | 1.1 | Yes | 1.1 | No | 1.0 | No |
| HSP 70 | -1.2 | Yes | -1.2 | Yes | -1.2 | Yes | -1.1 | No | 1.0 | No |
| BMP-1 | 1.2 | Yes | 1.2 | Yes | 1.1 | No | 1.0 | No | -1.0 | No |
| HMG-1 | 1.1 | Yes | 1.2 | Yes | 1.1 | No | 1.1 | No | 1.0 | No |
| Glutathione S-transferase Pi | -1.1 | Yes | -1.2 | Yes | -1.1 | No | -1.1 | No | -1.0 | No |
| C4b | -1.3 | Yes | -1.3 | Yes | -1.2 | No | -1.1 | No | -1.0 | No |
| PH | 1.2 | Yes | 1.1 | No | 1.1 | No | 1.0 | No | 1.0 | No |
| COX-2 | 1.1 | Yes | 1.1 | No | 1.1 | No | 1.0 | No | 1.0 | No |
| Phosphoglycerate mutase 1 | -1.8 | Yes | -1.4 | No | -1.4 | No | -1.2 | No | -1.2 | No |
| gpIIbIIIa | 1.2 | No | 1.5 | Yes | 1.3 | No | 1.3 | No | 1.1 | No |
| Trypsin 2 | 1.1 | No | 1.1 | Yes | 1.0 | No | -1.0 | No | 1.1 | No |
| Cytochrome P450 3A4 | -1.1 | No | -1.1 | Yes | -1.0 | No | -1.1 | No | -1.0 | No |
| IL-1b | -1.1 | No | -1.1 | Yes | -1.1 | No | -1.0 | No | -1.0 | No |
| DMP1 | -1.1 | No | -1.1 | Yes | -1.1 | No | -1.1 | No | -1.1 | No |
| Integrin aVb5 | -1.1 | No | -1.1 | Yes | -1.1 | No | -1.0 | No | 1.0 | No |
| NCK1 | -1.1 | No | -1.1 | Yes | -1.1 | No | -1.1 | No | -1.1 | No |
| B7-2 | -1.1 | No | -1.1 | Yes | -1.0 | No | -1.1 | No | -1.0 | No |
| VEGF121 | -1.1 | No | -1.1 | Yes | -1.0 | No | -1.1 | No | -1.1 | No |
| DUS3 | -1.1 | No | -1.1 | Yes | -1.0 | No | -1.0 | No | 1.0 | No |
| PRKACA | -1.3 | No | -1.3 | Yes | -1.2 | No | -1.1 | No | -1.0 | No |
| ASAHL | 1.2 | No | 1.2 | No | 1.4 | No | 1.4 | Yes | 1.4 | Yes |
| TF | -1.1 | No | -1.0 | No | -1.1 | No | -1.2 | Yes | -1.1 | No |
| PTK6 | -1.2 | No | -1.1 | No | -1.1 | No | -1.2 | Yes | -1.2 | No |
| Nidogen | 1.1 | No | 1.1 | No | 1.1 | No | 1.1 | No | 1.1 | Yes |
| ART | 1.1 | No | 1.1 | No | 1.1 | No | 1.1 | No | 1.2 | Yes |
| IGFBP-1 | 1.1 | No | 1.1 | No | 1.2 | No | 1.2 | No | 1.3 | Yes |
| Siglec-6 | 1.0 | No | 1.0 | No | 1.2 | No | 1.3 | No | 1.5 | Yes |
| FCRL3 | 1.0 | No | -1.0 | No | -1.0 | No | -1.1 | No | -1.1 | Yes |
| CRDL1 | 1.0 | No | 1.0 | No | 1.0 | No | 1.0 | No | 1.1 | Yes |
| IL-23 R | -1.0 | No | -1.0 | No | -1.1 | No | -1.1 | No | -1.1 | Yes |
| IGFBP-5 | -1.0 | No | 1.0 | No | 1.0 | No | 1.0 | No | 1.1 | Yes |
| ATS1 | -1.0 | No | -1.1 | No | -1.1 | No | -1.1 | No | -1.1 | Yes |
| PlGF | -1.1 | No | -1.1 | No | -1.2 | No | -1.3 | No | -1.3 | Yes |
Thirty-six proteins that were significant (Sig.) (q<0.25 and fold change >1.1) in at least one interval are shown. Adjustment was performed for BMI, maternal age, parity and smoking. FC: linear fold change, with negative values denoting lower while positive values denoting higher level in cases than in controls. See S2 File for full names of proteins, p-values and q-values as well as for which proteins change in abundance during gestation.