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. 2017 Jul 24;12(7):e0181016. doi: 10.1371/journal.pone.0181016

Table 4. Preterm and term preeclampsia in the second pregnancy according to gestational age and PROM in the first birth, 1998–2012.

(n = 153009).

1st pregnancy Preterm preeclampsia in 2nd pregnancy Term preeclampsia in 2nd pregnancy
Total n % OR 95% CI OR* 95% CI n % OR 95% CI OR** 95% CI
Spontaneous term birth 145141 287 0.2 Reference Reference 1394 1.0 Reference Reference
Spontaneous non-PROM
preterm birth
6172 44 0.7 3.6 (2.6–5.0) 3.3 (2.4–4.5) 110 1.8 1.9 (1.5–2.3) 1.8 (1.5–2.2)
Preterm PROM 1696 11 0.6 3.3 (1.8–6.0)
2.8 (1.5–5.2) 27 1.6 1.7 (1.1–2.4) 1.6 (1.1–2.3)

*Adjusted for the following variables in the 2nd pregnancy: maternal age, chronic hypertension, chronic renal disease, diabetes mellitus, birthweight centile <10 and >90 and inter-birth interval.

**Adjusted for the following variables in the 2nd pregnancy: marital status, chronic hypertension, diabetes mellitus, birthweight centile <10 and >90 and inter-birth interval.

PROM = preterm prelabour rupture of the membranes; OR = odds ratio; CI = confidence interval.