Table 1. Comparison of the rates of antibiotic changes after each testA.
| Verigene test | |||
|---|---|---|---|
| Total (n = 185) |
GP (n = 41) |
GN (n = 144) |
|
| Antibiotic changes | 51 (27.6%) [21.3–34.6%] |
17 (41.5%) [26.3–57.9%] |
34 (23.6%) [16.9–31.4%] |
| De-escalation to narrower-spectrum effective antibiotics | 36 (19.5%) [14–25.9%] |
13 (31.7%) [18.1–48.1%] |
23 (16%) [10.4–23%] |
| Switching to effective antibiotics from ineffective antibioticsB | 10 (5.4%) [2.6–9.7%] |
3 (7.3%) [1.5–19.9%] |
7 (4.9%) [2–9.8%] |
| Conventional test | |||
| Antibiotic change only after conventional identification | 57 (30.8%) [24.2–38%] |
12 (29.3%) [16.1–45.5%] |
45 (31.3%) [23.8–39.5%] |
| De-escalation to narrower-spectrum effective antibiotics | 41 (22.2%) [16.4–28.8%] |
9 (22%) [10.6–37.6%] |
32 (22.2%) [15.7–29.9%] |
| Switching to effective antibiotics from ineffective antibiotics | 1 (0.5%) [0–3%] |
0 [0–3%] |
1 (1.9%) [0–3.8%] |
| Antibiotic changes after conventional identification in addition to antibiotic changes after the Verigene test | 13C (7%) [3.8–11.7%] |
4 (9.8%) [2.7–23.1%] |
9 (6.3%) [2.9–11.5%] |
| De-escalation to narrower-spectrum effective antibiotics | 11D (5.9%) [3–10.4%] |
3 (7.3%) [1.5–19.9%] |
8 (5.6%) [2.4–10.7%] |
| Switching to effective antibiotics from ineffective antibiotics | 0 [0–1.6%] |
0 [0–3%] |
0 [0–2.1%] |
Note. Values indicate number (%) [95% confidence interval], unless otherwise indicated.
A The rates of antibiotic change within 2 days of rapid identification by the Verigene system and conventional identification and susceptibility tests.
B Including two episodes in which antibiotics were initiated after the Verigene test results became available.
C Including three episodes (two GPC and one GNR) in which changes were difficult to attribute to either method due to the short period of notification of differences in results.
D Including two episodes (one GPC and one GNR) in which changes were difficult to attribute to either method due to the short period of notification of difference in results.
Abbreviations. GP, gram-positive organisms; GPC, gram-positive cocci; GN, gram-negative organisms; GNR, gram-negative rods; NA, not available.