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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Mol Cell Neurosci. 2017 May 25;82:167–175. doi: 10.1016/j.mcn.2017.05.009

Fig. 5. KV1.3 modulates caspase 3 activity.

Fig. 5

A. Blockage of KV1.3 by PAP (10nM) or 4-AP (0.5µM) significantly decreased Meth/gp120-induced caspase-3/7 activity detected at 6 and 24 h time points. To illustrate Meth and gp120 increase of caspase-3/7 activity in combination and the blockage of Meth+gp120-induced increase by Kv1.3 blockers PAP and 4-AP, the 4 groups of data on the left (Ctrl, gp120, Meth and Meth+gp120) of Fig. 4A were reused in this figure. B. Western blots revealed a cleaved caspase-3 expression (upper). The bar graph (lower) illustrates increased fold after normalization with caspase-3. Data (mean ± SD) represent three experiments and each in triplicates. Statistical significance **p<0.01, ***p<0.001 vs ctrl, and #p < 0.05, ##p <0.01, vs meth+gp120-treated group.