Table 2. Selected single nucleotide variants of the candidate genes, their allele frequencies and Hardy–Weinberg equilibrium.

No.	CHR	Position GRCh37/hg19	Gene	Region	SNV	Minor allele	Major allele	MAF %	HWE p value
1	1	161160872	ADAMTS4	3’UTR	rs34884997	C	T	0.12	0.68
2	1	161161284	ADAMTS4	nonsynonymous	rs41270041	C	G	0.18	0.52
3	1	161163037	ADAMTS4	nonsynonymous	rs4233367	T	C	0.18	0.76
4	1	161168004	ADAMTS4	synonymous	rs33941127	T	C	0.40	0.85
5	1	161168189	ADAMTS4	nonsynonymous	rs34448954	T	C	0.13	0.42
6	2	113532083	IL1A	3’UTR	rs2856836	G	A	0.27	0.06
7	2	113532236	IL1A	3’UTR	rs1304037	C	T	0.28	0.06
8	2	113537223	IL1A	nonsynonymous	rs17561	A	C	0.27	0.06
9	2	113542960	IL1A	5’UTR	rs1800587	A	G	0.27	0.06
10	2	113587121	IL1B	downstream	rs2853550	A	G	0.29	0.65
11	2	113590390	IL1B	synonymous	rs1143634	A	G	0.13	0.69
12	7	22766246	IL6	5upstream	rs1800796	C	G	0.46	0.59
13	7	22766645	IL6	5upstream	rs1800795	C	G	0.13	0.10
14	7	22771156	IL6	synonymous	rs2069849	T	C	0.05	1.00
15	11	102709425	MMP3	synonymous	rs520540	A	G	0.33	0.10
16	11	102713465	MMP3	synonymous	rs602128	A	G	0.33	0.10
17	11	102713620	MMP3	nonsynonymous	rs679620	T	C	0.33	0.21
18	15	89382027	ACAN	synonymous	rs372041880	C	A	0.07	0.10
19	15	89382129	ACAN	nonsynonymous	rs16942318	A	C	0.05	0.05
20	15	89386652	ACAN	nonsynonymous	rs34949187	A	G	0.11	1.00
21	15	89388894	ACAN	nonsynonymous	rs148070768	G	A	0.14	0.26
22	15	89388905	ACAN	synonymous	rs16942341	T	C	0.07	1.00
23	15	89391160	ACAN	synonymous	rs2272023	C	A	0.34	0.42
24	15	89392689	ACAN	nonsynonymous	rs144501729	A	C	0.14	0.26
25	15	89398105	ACAN	synonymous	rs2351491	T	C	0.37	0.84
26	15	89398553	ACAN	nonsynonymous	rs35430524	A	C	0.05	0.05
27	15	89398553	ACAN	nonsynonymous	rs3743399	G	A	0.28	0.65
28	15	89398631	ACAN	nonsynonymous	rs938609	A	T	0.37	0.70
29	15	89400339	ACAN	nonsynonymous	rs2882676	A	C	0.47	0.46
30	15	89400680	ACAN	nonsynonymous	rs28407189	G	A	0.07	1.00
31	15	89400963	ACAN	nonsynonymous	rs79925540	T	G	0.16	0.48
32	15	89401109	ACAN	nonsynonymous	rs4932439	A	G	0.28	0.65
33	15	89401615	ACAN	synonymous	rs3825994	G	T	0.44	0.85
34	15	89401616	ACAN	nonsynonymous	rs76282091	C	G	0.16	0.48
35	15	89402051	ACAN	nonsynonymous	rs1042630	A	G	0.41	0.45
36	15	89402239	ACAN	synonymous	rs1042631	T	C	0.35	1.00
37	15	89402596	ACAN	synonymous	rs698621	G	T	0.38	0.85
38	15	89415247	ACAN	nonsynonymous	rs3817428	G	C	0.05	1.00
39	15	89417238	ACAN	nonsynonymous	rs1126823	G	A	0.36	0.84
40	17	76867017	TIMP2	synonymous	rs2277698	T	C	0.24	0.80
41	21	28291455	ADAMTS5	3’UTR	rs1444269	G	A	0.26	1.00
42	21	28291846	ADAMTS5	3’UTR	rs2298657	C	T	0.05	1.00
43	21	28292581	ADAMTS5	3’UTR	rs3746836	A	G	0.25	0.81
44	21	28293095	ADAMTS5	3’UTR	rs229072	T	A	0.48	0.27
45	21	28293117	ADAMTS5	3’UTR	rs229073	G	A	0.48	0.27
46	21	28293924	ADAMTS5	3’UTR	rs11700721	T	C	0.12	1.00
47	21	28294090	ADAMTS5	3’UTR	rs16979423	G	T	0.14	0.70
48	21	28294143	ADAMTS5	3’UTR	rs9978597	G	T	0.04	1.00
49	21	28296135	ADAMTS5	3’UTR	rs229078	T	G	0.22	1.00
50	21	28296324	ADAMTS5	3’UTR	rs151065	A	G	0.19	0.56
51	21	28296389	ADAMTS5	synonymous	rs3746839	G	A	0.08	1.00
52	21	28302355	ADAMTS5	nonsynonymous	rs226794	A	G	0.10	0.60
53	21	28338298	ADAMTS5	nonsynonymous	rs457947	G	C	0.07	0.46
54	21	28338423	ADAMTS5	synonymous	rs55933916	G	C	0.08	0.50
55	22	33253280	TIMP3	synonymous	rs9862	T	C	0.50	0.46
56	22	33253292	TIMP3	synonymous	rs11547635	T	C	0.07	0.42
57	22	33257322	TIMP3	3’UTR	rs1427384	C	T	0.19	0.53
58	22	33258050	TIMP3	3’UTR	rs2267184	T	C	0.16	0.48
59	22	33258288	TIMP3	3’UTR	rs1065314	C	T	0.17	0.32
60	23	47444879	TIMP1	nonsynonymous	rs5953060	C	G	0.43	0.66
61	23	47444985	TIMP1	synonymous	rs4898	C	T	0.43	0.66
62	23	47445286	TIMP1	nonsynonymous	rs6609533	G	A	0.43	0.66

CHR–chromosome number, SNV—single nucleotide variant, MAF–minor allele frequency, HWE—Hardy Weinberg equilibrium, UTR–untranslated region