Table 3. Childhood Cancer Registry of Piedmont 1976–2011: Number of cases (n) and annual percent change (APC) with corresponding 95% confidence interval.
| Childhood cancer registry of Piedmont 1976–20111 | 1976–2011 | 2000–20112 | ||||
|---|---|---|---|---|---|---|
| International Classification for Childhood Cancer, Third edition | 0–14 yrs | 0-14yrs | 15–19 | |||
| n | APC (95%CI) | n | APC (95%CI) | n | APC (95%CI) | |
| I Leukemias | 1168 | 0.6 (0.0; 1.2) | 378 | -0.6 (-5.4; 4.4) | 76 | 2.0 (-5.3; 9.9) |
| (a) Lymphoid leukemia | 931 | 0.9 (0.3; 1.4) | 306 | -0.2 (-4.7; 4.5) | 36 | 7.1 (-0.7; 15.7) |
| (b) Acute myeloid leukemia | 180 | -0.7 (-4.7; 3.5) | 46 | 2.1 (-35.3; 61.2) | 27 | 2.2 (-6.4; 11.4) |
| II Lymphomas | 449 | 1.7 (0.6; 2.7) (a) | 151 | -1.4 (-6.8; 4.3) | 194 | -1.7 (-5.6; 2.3) |
| -12.2 (-33.2; 15.4) | ||||||
| (a) Hodgkin lymphoma | 182 | 2.2 (-1.7; 6.3) | 70 | -2.3 (-9.1; 5.0) | 150 | -0.5 (-4.9; 4.1) |
| (b) Non-Hodgkin lymphoma | 156 | -1.0 (-5.0; 3.2) | 43 | 39.6 (-20.3; 144.6) | 38 | -3.2 (-13.1; 7.8) |
| III CNS tumors3 | 728 | 1.8 (0.9; 2.7) | 323 | -0.3 (-4.5; 4.2) | 81 | 4.6 (-3.0; 12.9) |
| (a) Ependymomas and choroid plexus tumors | 90 | 4.8 (-6.1; 16.9) | 41 | -4.5 (-13.0; 4.9) | 9 | (b) |
| (b) Astrocytomas | 288 | 1.2 (-0.4; 2.8) | 122 | -3.0 (-8.7; 3.1) | 28 | 5.6 (-5.4; 18.7) |
| (c) Intracranial and intraspinal embryonal neoplasms | 131 | 1.7 (0.1; 3.4) | 55 | 3.8 (-4.8; 13.1) | 7 | (b) |
| IV Neuroblastomas | 286 | 1.2 (0.2; 2.1) | 114 | -2.4 (-7.0; 2.5) | 6 | (b) |
| (a) Neuroblastoma and ganglioneuroblastoma | 282 | 1.1 (0.2; 2.1) | 113 | -2.5 (-7.3; 2.6) | 4 | (b) |
| V Retinoblastoma | 81 | 0.7 (-11.1; 14.2) | 24 | -9.9 (-49.5; 60.5) | 0 | (b) |
| VI Renal tumors | 167 | 0.2 (-1.1; 1.5) | 54 | -4.5 (-10.7; 2.2) | 2 | (b) |
| (a) Nephroblastoma and other nonepithelial renal tumors | 164 | 0.2 (-1.1; 1.5) | 53 | -4.5 (-10.6; 2.2) | 0 | (b) |
| VII Hepatic tumors | 42 | 3.8 (-13.4; 24.4) | 17 | 195.9 (6.6; 721.7) | 2 | (b) |
| (a) Hepatoblastoma | 30 | 8.1 (-13.4; 34.9) | 13 | 209.0 (-1.2; 866.5) | 0 | (b) |
| VIII Malignant bone tumors | 190 | 0.0 (-4.1; 4.4) | 51 | -4.1 (-14.8; 7.9) | 34 | 9.2 (-1.9; 21.4) |
| (c) Ewing tumor and related sarcomas of the bone | 74 | -5.9 (-18.9; 9.1) | 20 | -7.6 (-75.0; 242.1) | 11 | (b) |
| IX Soft tissue and other extraosseous sarcomas | 206 | 0.5 (-0.7; 1.7) | 64 | -4.8 (-12.2; 3.2) | 37 | -2.3 (-12.0; 8.6) |
| (a)Rhabdomyosarcomas | 144 | -1.9 (-8.3; 4.9) | 33 | 6.6 (-52.2; 137.7) | 9 | (b) |
| X Germ cell tumors | 94 | 2.4 (-5.9; 11.5) | 35 | -25.5 (-56.3; 27.1) | 56 | -3.1 (-9.7; 4.1) |
| (a), (b), (c) | 91 | 2.7 (-5.8; 11.9) | 35 | -25.5 (-56.3; 27.1) | 52 | -2.6 (-9.0; 4.2) |
| XI Other malignant epithelial neoplasms and malignant melanoma | 88 | 3.9 (-1.4; 9.5) | 41 | 27.9 (-20.4; 105.8) | 120 | 2.4 (-3.2; 8.3) |
| (a) Thyroid carcinomas | 37 | 20.4 (-2.3; 48.3) | 17 | 125.8 (-23.6; 567.5) | 59 | 3.7 (-6.3; 14.8) |
| (b) Malignant melanomas | 12 | 14.3 (-8.0; 42.1) | 5 | (b) | 31 | -1.1 (-13.5; 13.1) |
| XII Other and unspecified malignant neoplasms | 6 | (b) | 2 | (b) | 1 | (b) |
| All embryonal tumors | 801 | 1.1 (0.5; 1.6) | 289 | -0.6 (-3.6; 2.6) | 17 | -4.5 (-15.8; 8.3) |
| All non-embryonal tumors | 2857 | 1.2 (0.7; 1.6) | 965 | -1.0 (-4.0; 2.1) | 592 | 0.3 (-2.3; 2.9) |
| All tumor types | 3658 | 1.1 (0.8; 1.5) | 1254 | -0.9 (-3.4; 1.7) | 609 | 0.9 (-1.8; 3.5) |
1Data for adolescents (15–19) are available from 2000. Myelodysplasias are available from 2000 (n = 13).
2APC for the period 2000–2011 was calculated including myelodysplasias.
3 Number of cases and the APCs for CNS tumors were estimated from 1982–2011
(a) Breakpoint in 2007
(b) APC not estimated because of insufficient number of cases