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Indomethacin injection in SM22a-Cre; Rbpjflox/ mutant neonates.
| Phenotype | SM22a-Cre; Rbpjflox/ | Control littermates |
|---|---|---|
| Closed DA | 1/9 (11%) | 29/29 (100%) |
| Patent DA | 8/9 (89%) | 0/29 (0%) |
Indomethacin (6 mg/kg) was injected subcutaneously into pups within 12 hours of birth on day 0, or after caesarean delivery on day E18.5. After six hours, pups were euthanized and the ductus arteriosus scored for patency or closure. Mice from four litters are included in this table. DA: ductus arteriosus.
