Table 6.

Examples of consistently deregulated genes in both human gastric cancer and Tff1 knockout mouse low-grade dysplasia tissue samples, as compared with normal gastric tissue samples.

Human					Mouse
Symbol	Cytoband	Fold change	P value	PFDR	Symbol	Cytoband	Fold change	P value	PFDR	Gene Name
MMP12	11q22.3	6.25	5.00E−05	1.43E−02	Mmp12	9A1	3.42	1.20E−03	7.87E−02	matrix metallopeptidase 12 (macrophage elastase)
MMP9	20q11.2-q13.1	4.42	1.20E−03	6.20E−02	Mmp9	2 H1−H2	1.85	1.10E−02	2.40E−01	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
BGN	Xq28	3.9	2.73E−03	0.09	Bgn	X B	3	7.33E−05	0.02	biglycan
TIMP1	Xp11.3-p11.23	3.76	0.00E+00	6.20E−03	Timp1	X A1.3	3.14	1.30E−03	8.20E−02	TIMP metallopeptidase inhibitor 1
EPCAM	2p21	3.33	1.00E−02	1.40E−01	Epcam	17 E4	1.64	6.40E−03	1.90E−01	epithelial cell adhesion molecule
COL1A1	17q21.33	3	4.77E−03	0.11	Col1a1	11 D	3.8	5.00E−06	0	collagen, type I, alpha 1
IFITM1	11p15.5	2.91	8.30E−04	5.40E−02	Ifitm1	7	3.96	0.00E+00	3.40E−03	interferon induced transmembrane protein 1
VCAM1	1p32-p31	2.6	9.86E−03	0.14	Vcam1	3 G1	2.5	2.46E−02	0.34	vascular cell adhesion molecule 1
COL1A2	7q22.1	2.1	4.79E−02	0.27	Col1a2	6 A1	2.5	1.05E−04	0.02	collagen, type I, alpha 2
COL3A1	2q31	2.1	4.60E−02	0.26	Col3a1	1 C1.1	1.7	2.41E−03	0.11	collagen, type III, alpha 1
PDGFRB	5q33.1	2.1	1.46E−02	0.16	Pdgfrb	18 E1	3	5.95E−04	0.05	platelet-derived growth factor receptor, beta polypeptide
MMP14	14q11-q12	1.9	3.23E−03	0.09	Mmp14	14 C2	1.9	1.34E−02	0.21	matrix metallopeptidase 14 (membrane-inserted)
CLDN2	Xq22.3-q23	1.78	1.70E−02	1.70E−01	Cldn2	X F1	3.11	4.80E−04	4.80E-02	claudin 2
PLAU	10q24	1.7	1.33E−03	0.07	Plau	14 A3	2.1	1.47E−02	0.28	plasminogen activator, urokinase

Symbol, approved gene symbol; Fold change, relative gene expression fold change; P value, P value of ≤.05 was considered significant; PFDR, positive false discovery rate; Cytoband, gene location on subregions of a chromosome; Gene Name, full name of the gene.