Table 1.

The association of genetic risk variants with multiple myeloma risk in persons of European and African ancestry, including previously reported index single nucleotide polymorphisms and the most statitistically significant risk variants from a combined meta-analysis of the two populations.

Index SNPsa/most significantly associated SNPsb									Association in European ancestry				Association in African ancestry				Combined Meta
SNP	BP	Risk/Ref	Freq	OR		P-value			Freq	OR	P-value	Power	Freq	OR	P-value	Power	OR	P-value	P-het	r2 w/indexc
2p23.3
rs6746082a	25659244	A/C	0.76	1.29		1.22×10−7			0.79	1.15	5.17×10−2	0.96	0.55	1.04	3.77×10−1	0.80	1.07	7.51×10−2	0.24
rs6761076b	25607758	T/C							0.81	1.23	7.23×10−3		0.68	1.09	8.33×10−2		1.14	3.19×10−3	0.22	0.05/0.51
2q12.3
rs12614346a	107642482	A/G	0.33	1.39		1.70×10−5			0.31	1.00	9.45×10−1	0.99	0.16	1.00	9.81×10−1	0.99	1.00	9.74×10−1	0.95
rs13416655b	107621925	C/T							0.50	1.01	8.03×10−1		0.39	1.10	4.90×10−2		1.06	9.48×10−2	0.29	0.13/0.52
3p22.1
rs1052501a	41925398	G/A	0.20	1.32		7.47×10−9			0.22	1.23	4.42×10−3	0.99	0.63	1.06	2.21×10−1	0.99	1.11	9.86×10−3	0.09
rs143531651b	41816589	G/C							0.17	1.25	4.91×10−3		0.11	1.27	1.37×10−3		1.26	2.02×10−5	0.91	0.02/0.79
3q26.2
rs10936599a	169492101	G/A	0.75	1.26		1.74×10−13			0.79	1.12	8.41×10−2	0.92	0.93	1.08	3.84×10−1	0.73	1.11	5.65×10−2	0.75
rs9811216b	169487501	T/C							0.74	1.11	1.10×10−1		0.70	1.09	8.46×10−2		1.10	1.91×10−2	0.84	0.16/0.94
6p21.33d
rs2285803a	31107258	A/G	0.28	1.19		1.18×10−10		0.29		1.11	1.27×10−1	0.84	0.26	1.06	2.21×10−1	0.95	− d
7p15.3
rs4487645a	21938240	C/A	0.65	1.38		3.33×10−15		0.70		1.23	7.47×10−4	0.99	0.89	1.37	8.30×10−5	0.99	1.28	4.00×10−7	0.28
rs12540021b	21945563	G/A						0.75		1.24	6.30×10−4		0.89	1.43	2.27×10−5		1.31	1.27×10−7	0.19	0.71/0.67
17p11.2
rs4273077a	16849139	G/A	0.11	1.26		1.41×10−7		0.12		1.37	2.46×10−4	0.83	0.14	1.17	1.60×10−2	0.97	1.24	3.66×10−5	0.14
rs34562254b	16842991	A/G						0.11		1.45	2.39×10−5		0.13	1.25	1.33×10−3		1.32	2.93×10−7	0.17	0.33/0.90
22q13.1
rs877529a	39542292	A/G	0.44		1.23		2.29×10−16	0.45		1.21	4.31×10−4	0.97	0.48	1.11	1.47×10−2	0.99	1.15	4.31×10−5	0.21
rs139425b	39559742	C/G						0.46		1.21	4.43×10−4		0.71	1.21	5.54×10−4		1.21	8.41×10−7	0.93	0.18/0.95

^aIndex SNP in each region, OR and p-values from the literature (5, 6, 8).

^bMost significant Group A SNP in each region from the combined AA and EA meta-analysis

^cr² from 1KGP (AFR/EUR reference)

^dCombined analyses were not performed in the HLA region