Table 4.
Risk factors for cancers after LT for PSC*
| Risk factors | Univariate analysis Hazard Ratio (95% CI) | P | multivariate analysis Hazard Ratio (95% CI) | P |
|---|---|---|---|---|
| Recipient age at LT (per yr) | 1.03 ( 1.004–1.052) | 0.019* | 1.05 ( 1.02–1.10) | 0.002* |
| Donor age at LT (per Yr) | 0.992 ( 0.975–1.007) | 0.348 | - | - |
| Recipient gender (M:F) | 1.56 ( 0.93–2.69) | 0.091 | - | - |
| Smoking at time of LT (Yes: No) | 2.93 (0.48–9.55) | 0.585 | - | - |
| Type of Donor (Deceased: Living) | 1.65 (0.60–6.80) | 0.644 | - | - |
| Donor gender (M:F) | 1.63 ( 0.931–2.976) | 0.088 | - | - |
| Gender mismatch (Yes: No) | 0.75 (0.42–1.31) | 0.317 | - | - |
| Recipient CMV status( Positive: Negative) | 0.82 (0.47–1.45) | 0.480 | - | - |
| Donor CMV status( Positive: Negative) | 1.13 (0.65–1.97) | 0.668 | - | - |
| CMV mismatch (Yes: No) | 0.90 (0.47–1.62) | 0.727 | - | - |
| Roux-en-Y hepaticojejunostomy (Yes:No) | 0.64 (0.23–2.66) | 0.49 | ||
| Recurrent PSC (Yes:No) | 0.76 (0.44–1.26) | 0.29 | ||
| Era of Transplantation ( after 1995: before 1995) | 0.85 (0.49–1.47) | 0.558 | - | - |
| Pre-LT IBD | 1.23 (0.62–2.82) | 0.768 | - | - |
| Intact colon at time of LT (Y:N) | 1.47 (0.79–2.98) | 0.229 | - | - |
| MELD score at time of LT (per unit) | 1.06 (0.96–1.17) | 0.221 | - | - |
| White-cell count at time of LT (per unit) | 0.97 (0.87–1.07) | 0.568 | - | - |
| Neutrophils at time of LT (per unit) | 1.02 (0.89–1.14) | 0.706 | - | - |
| Lymphocytes at time of LT (per unit) | 0.62 (0.30–1.05) | 0.086 | - | - |
| Neutrophil to lymphocyte ratio (NLR) (per 1 increase )** | 1.10 (1.01–1.18) | 0.023* | 1.06 (0.98–1.14) | 0.123 |
| Hemoglobin at time of LT (per unit) | 0.78 (0.59–1.01) | 0.061 | - | - |
| Platelet count at time of LT (per unit) | 0.997 (0.993–1.001) | 0.122 | - | - |
| Prothrombin time-international normalized ratio at time of LT (per 0.1 increase) | 1.09 (1.005–1.17) | 0.039* | 1.12 (1.02–1.21) | 0.017* |
*
Excluding nonmelanoma skin cancers
**
Excluding patients with infection or on steroids at time of LT