Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 24;8:106. doi: 10.1038/s41467-017-00127-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — Progression of cardiomyopathy in PKP2-cKO mice. a Representative images of M-mode echocardiography recorded from left ventricle and right ventricle (LV; RV) of PKP2-cKO mice before (control; left), 21 dpi (middle) and 42 dpi (right). Notice scales on the right of each panel. b Masson’s trichrome staining of longitudinal heart sections of PKP2-cKO hearts at 14, 21, and 42 dpi (left, middle and right panels, respectively). c High contrast mask of the same sections emphasizing collagen deposition in the RV and LV in blue. Scale bar = 1 mm for all images. d Time course of change in RV area (measured by modified long axis B-mode echocardiography) in PKP2-cKO mice as a function of days after tamoxifen injection (dpi). Number of animals: n = 21 (0 dpi); n = 12 (14 dpi); n = 18 (21 dpi), n = 16 (28 dpi); n = 11 (35 dpi); n = 9 (42 dpi). e LV ejection fraction (LVEF) in PKP2-cKO, measured by long axis B-mode echocardiography. Number of animals: n = 21 (0 dpi), n = 13 (14 dpi), n = 19 (21 dpi), n = 16 (28 dpi), n = 15 (35 dpi), and n = 10 (42 dpi). For d, e, we obtained repeated measures from the same animals; statistical significance was calculated by paired Student’s t-test, comparing each value against its own control. f Kaplan–Meier survival curve of PKP2-cKO and control mice as a function of days after tamoxifen injection. A total of 16 PKP2-cKO and 10 control animals were followed. g Quantification of collagen deposition in the right (RV, red dots) and in the left (LV, blue dots) ventricle of control (CTL, n = 7) and PKP2-cKO hearts at 14 dpi (n = 5), 21 dpi (n = 10), 28 dpi (n = 8), 35 dpi (n = 8) and 42 dpi (n = 9). Statistical significance by one way ANOVA, RV and LV compared independently against corresponding control. For d, e, g: *p < 0.05, **p < 0.001