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. 2017 Jul 24;8:106. doi: 10.1038/s41467-017-00127-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Isoproterenol-induced arrhythmias in PKP2-cKO hearts. a Incidence of spontaneous, and of isoproterenol-induced (ISO) PVCs during 20 min of recording in anesthetized PKP2-cKO mice as a function of days post-tamoxifen injection (dpi). Data reported as percent of total animals studied per time point and condition; number of animals in parenthesis at top of each bar. Numbers inside bars indicate mean ± SEM of ventricular extrasystoles. b Example of ISO-induced non-sustained ventricular tachycardia (NSVT) in a PKP2-cKO mouse. Scale bar = 500 ms. c Example of ISO-induced fatal ventricular tachycardia/fibrillation (VT/VF) in a PKP2-cKO mouse 16 days post tamoxifen injection. Scale bar = 500 ms