Table 1.
Overrepresentation test of proteins up-regulated or down-regulated in larvae exposed to P. aeruginosa according to Pathway.
| Pathway | Proteins found | Expected proteins | Fold enrichment | P-value |
|---|---|---|---|---|
| PROTEINS UP-REGULATED IN ZEBRAFISH EXPOSED BY IMMERSION | ||||
| Hypoxia response via HIF activation | 21 | 8.15 | 2.58 | 1.90E-02 |
| PROTEINS DOWN-REGULATED IN ZEBRAFISH EXPOSED BY IMMERSION | ||||
| Integrin signaling pathway | 64 | 40.03 | 1.6 | 4.41E-02 |
| PROTEINS DOWN-REGULATED IN INJECTED ZEBRAFISH | ||||
| B cell activation | 34 | 16.34 | 2.08 | 1.38E-02 |
| Endothelin signaling pathway | 41 | 22.61 | 1.81 | 4.96E-02 |
| PROTEINS UP-REGULATED ONLY IN INJECTED ZEBRAFISH | ||||
| Axon guidance mediated by netrin | 21 | 6.95 | 3.02 | 2.03E-03 |
| Cytoskeletal regulation by Rho GTPase | 32 | 16.13 | 1.98 | 4.83E-02 |
| Inflammation mediated by chemokine and cytokine signaling pathway | 58 | 34.34 | 1.69 | 2.11E-02 |
| PROTEINS UP-REGULATED ONLY IN ZEBRAFISH EXPOSED BY IMMERSION | ||||
| Integrin signaling pathway | 50 | 28.91 | 1.73 | 3.49E-02 |
| Angiogenesis | 53 | 31.28 | 1.69 | 3.73E-02 |
Up-regulated and down-regulated proteins in zebrafish injected with P. aeruginosa PAO1 or co-incubated with P. aeruginosa PAO1, with respect to the controls, were analyzed according to Pathway.