Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 24;7:6301. doi: 10.1038/s41598-017-06443-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Differential microvesicles signalling in L. pneumophila infection of macrophages. The infection of macrophage-like THP-1 cells with L. pneumophila induces the release of pro-inflammatory cytokines and EVs, eukaryotic exosomes and prokaryotic OMVs. While alveolar epithelial cells mostly respond to the cytokines with a pro-inflammatory response and to a weaker extent to the exosomes, macrophages respond to the released EVs. Here, the bacterial OMVs carrying the LPS are the main stimulating agent.