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. 2017 Jul 24;7:6300. doi: 10.1038/s41598-017-06684-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Seizure characteristics and signal quality of the non-treated animals. (a,b and c) Group data shows the Time in Seizure (a), average seizure duration (b) and seizure rate (c) over the weeks of observation (each measure is normalized to its corresponding mean ‘Week 1’ value for each animal). Shaded area represents ± SD. (d) Example LFP traces and continuous wavelet spectra of the recordings of one representative rat demonstrating the stable signal quality over the weeks. *p < 0.01 vs Week 2, one-way ANOVA (a,c), Kruskal-Wallis test (b), both followed by post hoc HSD.