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. 2017 Jul 24;7:6348. doi: 10.1038/s41598-017-05740-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Spontaneous skin inflammation develops in Nfkbiz ^−/− mice. (A) Representative skin phenotype and histology of skin biopsy from Nfkbz ^+/− and Nfkbiz ^−/− mice at age 10 weeks. Scale bar = 50 µm. (B) Disease incidence and progression of dermatitis in Nfkbiz ^+/− and Nfkbiz ^−/− mice (n = 20). Dermatitis incidence (score ≥ 3) is shown as a percentage. (C) Trans-epidermal water loss (TEWL) and serum IgE antibody levels in Nfkbiz ^+/− and Nfkbiz ^−/− mice. (D) Cytokines and chemokine levels in a skin homogenate. (E) Confocal microscopy of skin biopsies from Nfkbiz ^+/− and Nfkbiz ^−/− mice. Scale bar = 50 μm. Data are representative of three independent experiments. All data are mean ± s.e.m. *p < 0.05, **p < 0.01.