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. 2017 Jul 24;7:6348. doi: 10.1038/s41598-017-05740-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Topical application of S. xylosus leads to differentiation of Th17 cells in skin of Nfkbiz ^−/− mice. (A) Flow cytometry analysis of IL-17A and IL-22 production in CD4⁺ cells from skin of PBS, heat-killed S. xylosus (HK-S.x), or S. xylosus(S.x)-inoculated Nfkbiz ^−/− mice. (B) Cytokine and chemokine levels in skin homogenate. Data are representative of three independent experiments. Data are mean ± s.e.m. *p < 0.05, **p < 0.01.