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Partition Coefficients (expressed as Kp and logD) of doxorubicin in DMPC:SM [8:2] and DMPC:SM:Chol [7:1.5:1.5] at pH 7.4 and 37 °Ca.
| Model | Kp | Experimental logD |
|---|---|---|
| DMPC:SM | 8195 ± 406 | 3.91 ± 0.02 |
| DMPC:SM:Chol | 8707 ± 523 | 3.94 ± 0.03 |
aAll values represent the mean ± standard deviation (n = 3).
*p < 0.05 statistically different from the other model.
