Table 5.

Interactions of coffee drinking and sweeteners use in relation to major depression risk^*.

Total coffee drinking	Use of NNS
	Never	Any†
Never	1.0 (Reference)	1.20 (1.05–1.38)
>0–<4 cups/day	1.04 (0.92–1.18)	1.13 (1.00–1.28)
≥4 cups/day	1.44 (1.18–1.75)	1.39 (1.13–1.70)

NNS = non-nutritive sweetener. *ORs and 95% CIs were computed with adjustment for age, sex, ethnicity, education, province of residence, smoking status, alcohol drinking, self-reported cardiovascular disease and diabetes, healthy eating index (in tertiles), total physical activity (in MET-min/week tertiles), and BMI. ^†Non-nutritive sweetener use in coffee or tea or diet drinks.