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. 2017 Jul 24;7:6280. doi: 10.1038/s41598-017-06743-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Phylogenetic tree of the oral microrganisms targeted by the OralArray. The tree was obtained from the entire positive set used for the probe design. The neighbor-joining method was used to infer evolutionary history. The evolutionary distances were computed using the maximum composite likelihood method and units correspond to the number of base substitutions per site. The analysis involved 383 nucleotide sequences (Supplementary Table S2). All positions containing gaps and missing data were eliminated. Evolutionary analyses were conducted by using MEGA6 software.