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. 2017 Jul 24;7:6280. doi: 10.1038/s41598-017-06743-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sensitivity of the OralArray on DNA mixes. Artificial mixes of 16 S rRNA amplicons were subjected to LDR-UA analysis, sSNR values were plotted vs ng of each DNA amplicon. sSNR values were obtained with decreasing amounts of DNA mixes containing: (a) S. oralis, S. aureus, P. micra, P. acidifaciens, A. odontolyticus, and E. corrodens 16 S rRNA amplicons (8–1 ng each); (b) G. morbillorum, L. buccalis, F. nucleatum, T. denticola, C. sputigena, and P. gingivalis 16 S rRNA amplicons (8–1 ng each); (c) H. parainfluenzae, A. actinomycetemcomitans, C. sputorum, P. denticola, P. intermedia, and P. melaninogenica 16 S rRNA amplicons (8–1 ng each); (d) S. mutans, L. acidophilus, S. noxia, and V. parvula 16 S rRNA amplicons (8–1 ng each); (e) S. oralis, G. morbillorum, A. odontolyticus, and P. melaninogenica 16 S rRNA amplicons (8–1 ng each) added with human genomic DNA up to 100 ng of total DNA (68–96 ng).