Table 3.
Identification of plasma lipid biomarkers.
| Primary ID | Common name | Models where significant |
|---|---|---|
| X0.99_586.3136 | LPC(20:5) | WC, leptin, Pc4 |
| X1.03_562.3132 | LPC(18:3) | BMI, WC, leptin, total adipo |
| X1.08_612.3280 | LPC(22:6) | BMI, WC, leptin |
| X1.17_564.3289 | LPC(18:2) | BMI, WC, leptin, total adipo, C-peptide |
| X1.21_476.2768 | LPE(18:2) | BMI, WC, leptin, total adipo |
| X1.22_544.2648 | LPS(20:4) | BMI, total adipo |
| X1.35_669.3989 | Unknown | SVD |
| X1.42_566.3497 | LPC(18:1) | BMI, WC, leptin, total adipo, C-peptide |
| X1.49_478.2927 | LPE(18:1) | BMI, total adipo |
| X1.51_592.3513 | LPC(20:2) | BMI, WC, leptin, total adipo, SVD |
| X1.59_554.3446 | LPC(17:0) | BMI, WC |
| X1.91_594.3757 | LPC(20:1) | WC, leptin |
| X2.65_255.2331 | Palmitic acid | Pc4 |
| X3.52_421.3076 | TLTI | BMI, WC, SVD |
| X4.18_794.5050 | Unknown | BMI, WC, total adipo |
| X4.37_881.5140 | PI(16:0_22:6) | Pc4 |
| X5.23_826.5592 | PC(18:2_18:2) | BMI, WC, total adipo |
| X5.43_1068.6601 | Unknown | BMI, WC, leptin |
| X5.90_810.5600 | PC(O-16:0_20:5) | WC, leptin |
| X6.50_828.5729 | PC(18:1_18:2) | BMI, WC, total adipo |
| X7.15_786.5626 | PC(O-16:1_18:2) | BMI, WC, leptin, total adipo, C-peptide |
| X7.32_864.6056 | PC(O-18:1_22:5) | WC, leptin |
| X7.47_788.5783 | PC(O-16:0_18:2) | WC, total adipo |
| X8.17_830.6155 | PC(18:0_18:2) | SVD |
| X8.23_950.6408 | TLTI | Pc4 |
| X8.24_880.6145 | PC(20:1_20:4) | SVD |
| X8.44_716.5227 | PE(16:0_18:1) | total adipo, C-peptide |
| X8.61_1038.473 | TLTI | WC, C-peptide |
| X8.61_766.5363 | PE(18:0_20:4) | WC, leptin, total adipo, C-peptide |
| X8.67_864.6048 | PC(O-18:0_22:6) | Pc4 |
| X8.90_880.6027 | PC(18:0_22:5) | BMI, WC, leptin |
| X8.93_856.6036 | PC(18:0_20:3) | BMI, WC, leptin, C-peptide |
| X9.01_1128.5388 | TLTI | WC, leptin |
| X9.03_842.5446 | TLTI | Pc4 |
| X9.42_814.5927 | PC(O-18:1_18:2) | BMI, WC |
| X9.45_1261.8069 | TLTI | Pc4 |
| X9.66_768.5494 | PE(18:0_20:3) | leptin, C-peptide |
| X9.96_1034.5762 | TLTI | Pc4 |
| X10.11_1381.848 | Unknown | WC, Pc4 |
| X10.19_802.5695 | TLTI | Pc4 |
| X10.33_871.6904 | SM(d19:1/24:1) | WC, leptin, Pc4 |
| X11.20_1012.7670 | TLTI | Pc4 |
| X12.14_850.7682 | TLTI | SVD |
| X12.43_934.7918 | TLTI | SVD |
| X13.07_988.794 | TLTI | Pc4 |
| X13.10_920.7410 | TLTI | Pc4 |
| X13.11_919.7343 | TLTI | Pc4 |
| X14.31_881.7973 | TLTI | Pc4 |
| X14.33_869.3325 | TLTI | Pc4 |
| X14.35_1062.754 | TLTI | Pc4 |
| X14.38_880.7349 | TLTI | Pc4 |
The structural of identification of plasma lipids was performed based if m/z: was significant in two or more models from single marker regression analyses of responses, or had a radii ≥ 0.15 in singular value decomposition analysis, or was one of the top ten lipids positively and inversely associated with principal component 4. Plasma lipids meeting this criterion that were too low to identify (TLTI) are listed. Plasma lipid common names determined by lipid structure identification using Lipid Maps and Human Metabolome databases, and manual confirmation of mass spectra. The “_” between fatty acids in glycerophospholipid structures is used, since the position at the sn1 and sn2 position cannot be determined. Plasma lipids listed as unknown did not match a lipid library database search or exhibit a fragmentation pattern indicative of phospholipids in ms/ms analyses. Spectra of unknowns are listed in Supplementary Table 9. Body mass index (BMI), waist circumference (WC), total adiponection (total adipo), principal component 4 (Pc4) and singular value decomposition (SVD).