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. 2017 Jul 25;8:536. doi: 10.3389/fphys.2017.00536

Figure 1.

Figure 1

Myocardin expression in aortic smooth muscle cells (SMC) from patients with thoracic aortic aneurysm with tricuspid aortic valve (TAV) or bicuspid aortic valve (BAV) and controls (C). (A) Relative mRNA levels for MYOCD (myocardin) in SMC from patients with aortic aneurysm (TAV, n = 11; BAV, n = 14), and control cells (C, n = 13). The significance of gene expression differences between groups was evaluated by a two-tailed Mann–Whitney test; line represents the median; *p < 0.05. (B) Scatter plots showing correlations of MYOCD and SMC marker genes ACTA2, TAGLN, CNN1, VIM expression levels in SMC of patients with aortic aneurysm with BAV, TAV, and healthy controls. mRNA levels were analyzed by qPCR and normalized to GAPDH. The x- and y-axis show log RQ (relative quantification = 2−ΔΔCt). r, Spearman correlation coefficient; p, p-value. P-values less than 0.05 were considered to be statistically significant. Statistically significant correlations are highlighted by red rectangles.