Table 2.
PD effluent parameters.
| AlaGln 0 mM | AlaGln 8 mM | AlaGln 16 mM | p-valuea | p-valueb | |
|---|---|---|---|---|---|
| total cell count (G/L) | |||||
| PET (4 h) | 0.012 (0.002–0.032) | 0.01 (0.004–0.03) | 0.008 (0.004–0.061) | 0.84 | 0.81 |
| overnight dwell (16 h) | 0.036 (0.015–0.06) | 0.036 (0.022–0.1) | 0.029 (0.015–0.339) | 0.19 | 0.99 |
| ON-Differential (rel%) | |||||
| monocytes/macrophages | 90 (78–95) | 90 (81–94) | 87.5 (86–99) | 0.81 | 0.81 |
| lymphocytes | 4.5 (2–19) | 5.5 (2–11) | 6 (0–12) | 0.63 | 0.63 |
| neutrophils | 2.5 (0–10) | 5.5 (1–10) | 1.5 (0–7) | 0.66 | 0.63 |
| eosinophils | 0 (0–2) | 0 (0–1) | 1.5 (0–5) | 0.99 | 0.13 |
| basophils | 0 (0–1) | 0 (0–1) | 0 (0–1) | 0.99 | 0.99 |
| Plasma IL-6 (pg/ml) c | 6.5 (4.6–10) | 7.9 (4.5–9.6) | 6.4 (4.5–10.7) | 0.84 | 0.99 |
| basal IL6 (pg/ml) | |||||
| PET (1 h) | 58 (37.4–82.4) | 88.1 (38.9–124.8) | 59 (50.4–128.1) | 0.16 | 0.31 |
| PET (4 h) | 118.9 (79.5–138.8) | 124.9 (61.7–148.4) | 96.3 (70.0–151.4) | 0.99 | 0.84 |
| overnight dwell (16 h) | 355.8 (176.2–426.4) | 434.1 (197.5–632.9) | 310.6 (250.4–1108) | 0.31 | 0.56 |
| basal IL-8 (pg/ml) d | |||||
| PET (4 h) | 9.7 (5.7–13.4) | 7.7 (5.2–16.5) | 7.8 (2.5–13.3) | 0.84 | 0.22 |
| overnight dwell (16 h) | 12.5 (8.1–23.7) | 16.3 (10.5–32.3) | 16 (11.4–27.4) | 0.16 | 0.16 |
| Clinical chemistry e | |||||
| Albumin loss (g) | 1.3 (1.0–1.5) | 1.3 (0.9–1.6) | 1.3 (0.9–1.6) | 0.99 | 0.88 |
| Total protein loss (g) | 1.8 (1.3–1.8) | 1.6 (1.2–2.1) | 1.4 (1.2–2.2) | 0.63 | 0.86 |
| Sodium dip (mmol/l) | 5.5 (1–9) | 4.0 (−1–7) | 4.5 (1–6) | 0.19 | 0.19 |
| D4 h/D0 h Glucose | 0.20 (0.14–028) | 0.22 (0.14–0.30) | 0.27 (0.002–0.42) | 0.50 | 0.63 |
| D/P creatinine | 0.85 (0.78–1.06) | 0.82 (0.69–0.96) | 0.82 (0.10–0.91) | 0.63 | 0.16 |
| D/P BUN (4 h) | 1.03 (0.92–1.09) | 1.00 (0.95–2.22) | 0.99 (0.96–1.02) | 0.99 | 0.22 |
| D/P albumin (4 h) | 0.01 (0–0.02) | 0.02 (0.01–0.02) | 0.01 (0.01–0.06) | 0.53 | 0.94 |
| D/P total protein (4 h) | 0.01 (0–0.02) | 0.01 (0.01–0.02) | 0.01 (0–0.02) | 0.63 | 0.69 |
| CA 125 (kU/l) | 37.0 (21.7–65.8) | 39.5 (21.5–56.3) | 37.4 (18.6–46.3) | 0.81 | 0.16 |
| Ultrafiltration (ml) | 560 (30–1015) | 484 (119–794) | 469 (−141–931) | 0.31 | 0.06 |
Data are represented as median (range) of all 6 patients enrolled in the feasibility trial. Wilcoxon matched-pairs signed rank test was used to calculate p-values. aComparison control without AlaGln versus 8 mM AlaGln in PDF. bComparison control without AlaGln versus 16 mM AlaGln in PDF. cIL-6 was measured in EDTA plasma samples at the 2 h time point of the PET. dBasal IL-8 was not detectable in 1 h PET sample. eDialysate parameters are measured at the 4 h PET time point. To evaluate the peritoneal permeability for small solutes, dialysate-to-plasma ratios (D/P) of creatinine, BUN, albumin and total protein were calculated from the 4 h effluent value and the plasma values at 2 hours. The permeability for glucose was estimated as the ratio between the dialysate glucose concentration at 4 h to that at 0 h dwell (D4/D0). As indirect measure of free water transport, the difference between dialysate sodium concentration at 1 h and that at baseline (sodium dip) was calculated. Uncorrected p-values are shown.