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NLRP3 inflammasome and metabolic disorders.
| Metabolic disorders | Activators/signals | Major contributors |
|---|---|---|
| Atherosclerotic disease | Cholesterol crystals | IL-1β, IL-18 |
| Type 2 diabetes | Amylin/IAPP, glucose, palmitate, and ceramide | IL-1β |
| Obesity | High fat diet induces cholesterol crystal formation | IL-1β, IL-18 |
| Gouty arthritis | Monosodium urate (MSU) | IL-1β |
