Table 2.
Effect of the APOE genotype on anthropometric variables, blood pressure, fasted plasma- and serum- profiles in the LIPGENE Dietary Fatty Acid Intervention Study (n = 442; males n = 194, females n = 248).
| All (n = 442) | E2 carriers (n = 46) | E3/E3 (n = 264) | E4 carriers (n = 115) | E2/E4 (n = 17) | P | |
|---|---|---|---|---|---|---|
| Age (y) | 55 ± 1 | 56 ± 1 | 54 ± 1 | 55 ± 1 | 53 ± 2 | 0.026 |
| BMI (kg/m2) | 31.6 ± 1.0 | 32.6 ± 0.7 | 32.6 ± 0.3 | 32.4 ± 0.5 | 31.6 ± 1.1 | 0.316 |
| Waist (cm) | 104 ± 3 | 107 ± 2 | 106 ± 1 | 105 ± 1 | 104 ± 2 | 0.894 |
| Diastolic BP (mm Hg) | 86 ± 2 | 87 ± 1 | 86 ± 1 | 86 ± 1 | 87 ± 2 | 0.729 |
| Systolic BP (mm Hg) | 137 ± 4 | 137 ± 2 | 139 ± 1 | 140 ± 1 | 137 ± 4 | 0.744 |
| TC (mmol/L) | 5.15 ± 0.69 | 4.98 ± 0.16a | 5.38 ± 0.06b | 5.53 ± 0.09b | 5.03 ± 0.21 | 0.015 |
| LDL-C (mmol/L) | 3.08 ± 0.11 | 2.67 ± 0.16a | 3.27 ± 0.06b | 3.57 ± 0.09b | 3.14 ± 0.18 | 0.001 |
| NEFA (µmol/L) | 610 ± 27 | 675 ± 37 | 597 ± 14 | 641 ± 23 | 593 ± 58 | 0.129 |
| HDL-C (mmol/L) | 1.08 ± 0.04 | 1.13 ± 0.05 | 1.11 ± 0.02 | 1.08 ± 0.02 | 1.14 ± 0.09 | 0.234 |
| TC:HDL-C ratio | 5.12 ± 0.20 | 4.65 ± 0.21a | 5.05 ± 0.07 | 5.38 ± 0.14b | 4.92 ± 0.49 | 0.035 |
| TRL-C (mmol/L) | 1.82 ± 0.13 | 0.46 ± 0.05 | 0.34 ± 0.01a | 0.45 ± 0.04b | 0.47 ± 0.10 | 0.493 |
| TAG (mmol/L) | 0.47 ± 0.05 | 1.91 ± 0.16 | 1.71 ± 0.05 | 1.94 ± 0.10 | 1.86 ± 0.18 | 0.371 |
| TRL-TAG (mmol/L) | 0.93 ± 0.09 | 0.89 ± 0.09 | 0.82 ± 0.03 | 0.98 ± 0.07 | 0.89 ± 0.15 | 0.286 |
| Apo AI (mg/L) | 1.37 ± 0.03 | 1.43 ± 0.04 | 1.41 ± 0.02 | 1.38 ± 0.02 | 1.42 ± 0.07 | 0.590 |
| Apo B (mg/L) | 0.95 ± 0.02 | 0.88 ± 0.04a | 1.03 ± 0.01b | 1.09 ± 0.02b | 0.90 ± 0.04 | < 0.001 |
| Apo B48 (mg/L) | 0.85 ± 0.13 | 0.67 ± 0.10 | 0.79 ± 0.06 | 0.78 ± 0.09 | 1.25 ± 0.33 | 0.197 |
| TRL apo B (mg/L) | 56.7 ± 6.1 | 51.1 ± 7.3 | 44.9 ± 2.4 | 59.5 ± 5.4 | 60.6 ± 11.7 | 0.283 |
| Apo CII (mg/L) | 46.75 ± 2.2 | 49.0 ± 3.0 | 44.7 ± 1.0 | 45.7 ± 1.8 | 52.1 ± 4.6 | 0.353 |
| Apo CIII (mg/L) | 152 ± 7 | 169 ± 10 | 157 ± 3 | 159 ± 5 | 159 ± 12 | 0.777 |
| Apo E (mg/L) | 43.8 ± 3.11 | 55.1 ± 4.64a,c | 39.9 ± 0.73b,c | 38.0 ± 1.37b | 50.4 ± 1.98c | < 0.001 |
| Glucose (mmol/L) | 5.92 ± 0.21 | 6.04 ± 0.11 | 5.91 ± 0.06 | 6.10 ± 0.12 | 5.92 ± 0.25 | 0.113 |
| Insulin (µIU/mL) | 9.0 ± 1.5 | 9.7 ± 0.9 | 10.1 ± 0.4 | 10.4 ± 0.6 | 9.0 ± 1.5 | 0.996 |
| HOMA-IR | 2.51 ± 0.56 | 2.64 ± 0.25 | 2.65 ± 0.10 | 2.87 ± 0.19 | 2.51 ± 0.57 | 0.892 |
| CRP (mg/L) | 5.18 ± 0.20 | 5.32 ± 0.77 | 5.51 ± 0.24a | 4.48 ± 0.41b | 4.45 ± 0.41 | 0.028 |
Abbreviations: BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; NEFA, non-esterified fatty acid; TAG, triacylglycerol; TRL-C, triglyceride rich lipoprotein cholesterol fraction; TRL-TG, triglyceride rich lipoprotein triglyceride fraction; CRP, C-reactive protein. Values are means ± s.e.m. Models were adjusted for center, gender, age and BMI. Where P for genotype <0.05, a post-hoc Bonferroni test were used to determine a between group effect. Superscript letters a and b denote significant differences in means (P < 0.05).