. 2017 Jul 24;7:6211. doi: 10.1038/s41598-017-06089-z

Table 1.

The main methods used to measure clot dissolution during in vitro thrombolysis.

Methods	Principle	Non-contact	Lysis kinetics	Price	Main limits
Weight¹⁷	Weight of the clot before and after treatment	No	No	+++	Influenced by dehydration;
Weight¹⁷	Weight of the clot before and after treatment	No	No	+++	No volume measurement
Imaging¹⁸	Taking an image of one side of the clot	Yes	Yes	++	2D evaluation;
Imaging¹⁸	Taking an image of one side of the clot	Yes	Yes	++	Approximate volume
Optical coherence tomography¹²	Light waves are reflected at different depths within the sample	Yes	Yes	—	Low light penetration
Optical coherence tomography¹²		Yes	Yes	—	Radiolabeled
D-Dimer dosage¹⁹	Radiolabeled iodine is integrated into the fibrin molecule and liberated during thrombolysis	Yes	Yes	—	No volume measurement;
D-Dimer dosage¹⁹		Yes	Yes	—	radioactive component
Hydrodynamic parameter¹⁰	Difference in pressure before and after clot dissolution	Yes	Yes	+	Requires flow
Turbidity of the solution²⁰	Thrombolysis liberates particles, thereby increasing the turbidity of the solution	+/−	Yes	+	Not possible with flow
High resolution ultrasound imaging^{Present study}	3D ultrasound imaging of blood clots	No	Yes	+	Requires the presence of red blood cells in the clot