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. 2017 Jul 24;7:6250. doi: 10.1038/s41598-017-06570-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genipin promotes neurite extension of human iPSC-derived neural progenitors cultured on 2D laminin surfaces. (A) Phase contrast image showing an hiPSC-derived neural aggregate with no genipin present. (B) Phase constrast image showing an hiPSC-derived neural aggregate treated with 0.05 mM genipin. (C) Quantification of the neurite length and branch points for each of the aforementioned groups. The group treated with 0.05 mM genipin showed increased neurite length and increased numbers of branch points, indicating more mature levels of differentiation. *Indicates p < 0.05 compared to control. Each group is represented by its mean average (technical n = 71 measurements) with error bars indicating the standard error of the mean. Each image represents a single neural aggregate with an initial seeding density of 4000 cells/aggregate (biological n = 3).