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. 2017 Jul 24;7:6250. doi: 10.1038/s41598-017-06570-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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hiPSC-derived neural progenitors differentiate into neurons when seeded inside of mechanically stable genipin cross-linked fibrin scaffolds. (A) Neural aggregates seeded in fibrin degraded the fibrin within 5 days and attached to the plate bottom, whereas (B) neural aggregates seeded in 2.5 mM fibrin-genipin scaffolds differentiated within the 3-D scaffold which remained intact for 2 weeks. Each image represents a single neural aggregate with an initial seeding density of 4000 cells/aggregate. Image D is representative of 10 out of 24 biological replicates, which correlates with the percentage of neural aggregates showing signs of differentiation at the time of seeding.