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. 2017 Jul 24;7:6238. doi: 10.1038/s41598-017-06217-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HLJDT-M but not HLJDT treatment reduces Aβ peptide levels in 3XTg-AD mice. SDS-soluble (a) and formic acid-soluble (b) Aβ1-40 and Aβ1-42 levels from the right brain hemisphere were measured by sandwich ELISA. Both Aβ1-40 and Aβ1-42 were reduced in the brains lysates of HLJDT-M-treated (**p < 0.01) animals. Compared to the HLJDT-M treatment groups, HLJDT significantly increased both detergent and acid-soluble Aβ1-40 and Aβ1-42 levels. Values denote group mean ± SEM. The statistical significant difference between the groups are denoted as *p < 0.05, **p < 0.01, ***p < 0.001 vs. vehicle control; ^#p < 0.05, ^###p < 0.001 for 1 g/kg HLJDT-M vs. 1 g/kg HLJDT and ^p < 0.05, ^^^p < 0.001 for 1 g/kg HLJDT-M vs. 1 g/kg HLJDT. N = 10 mice per group.