Table 2.

Relationship between MEG3 methylation in plasma and clinical pathological characteristics.

Clinical pathological characteristics		Methylation		P	R	ORa (95% CI)
		M	MU, U
Lymph nodes metastasis	Positive	52	12	<0.001	0.435	7.526 (3.577–15.835)
	Negative	38	66
HPV infection	Positive	82	48	<0.001	0.353	6.406 (2.718–15.099)
	Negative	8	30
Tumor size	≥4 cm	46	30	0.100
	<4 cm	44	48
Differentiation	Poorly	34	30	0.927
	Well and Moderately	56	48
Depth of invasion	>2/3	52	36	0.132
	≤2/3	28	42
LVSI	Positive	50	34	0.122
	Negative	40	44
Age	>50	42	40	0.551
	≤50	48	38
Menopause	Yes	30	36	0.090
	No	60	42
Histology	Squamous	76	60	0.216
	Adenocarci-noma	14	18

^aOR (Odds ratio).