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. 2017 Jul 24;7:6224. doi: 10.1038/s41598-017-04574-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PBPK modelling in mice. Plasma concentration profiles from three different sampling sites where used in this study: the right heart chamber (1) and the portal vein (2) (both contributing to the liver inflow) and the hepatic vein (3) (representing the liver outflow). Due to the detailed structure of PBPK-models (left), it was possible to include all three sampling sites into the model at the same time (upper right). The volume fractions of the periportal and the pericentral zone of the liver lobule (lower right) were set according to the previously determined fractions of expression (Table 1).