Table 3.

Parameters of the active clearance processes.

Substance	Parameters
Caffeine	CLLiver = 0.59 1/min; CLrenal = 0.0324 1/min
Paraxanthine	CLLiver = 3.5E-7 1/min; CLrenal = 0.00926 1/min
Midazolam	1′-HM: kcat = 80.82 1/min; Km = 0.95 µmol/l; 4′-HM: kcat = 28.73 1/min; Km = 8.43 µmol/l
1′-Hydroxymidazolam	CLLiver = 15.6 1/min
Torsemide	CLLiver = 1.93 1/min; CLrenal = 0.64 1/min
Hydroxytorsemide	CLLiver = 15.3 1/min; CLrenal = 79.6 1/min
Codeine	CLLiver = 1.60 1/min; CLrenal = 0.21 1/min
Talinolol	CLLiver = 2.95 1/min; CLrenal = 39.76 1/min
Pravastatin	CLLiver = 2.52 1/min; CLbilary = 0.00000457 1/min; CLrenal = 500 1/min