Table 4.
Mean AUCs (±SD) [µmol*min/l] of the experimental PK data for the healthy (hlt) and the damaged (tox) case at the three sampling sites.
| Drug | Caffeine | Midazolam | Torsemide | Codeine | Talinolol | Pravastatin | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| hlt | tox | hlt | tox | hlt | tox | hlt | tox | hlt | tox | hlt | tox | |
| Hepatic vein | 3638 ± 280 | 5981 ± 227 | 58 ± 6 | 256 ± 19 | 6398 ± 352 | 9312 ± 722 | 189 ± 19 | 340 ± 66 | 29 ± 3 | 166 ± 13 | 249 ± 110 | 2371 ± 711 |
| Portal vein | 3374 ± 194 | 5431 ± 333 | 78 ± 7 | 247 ± 15 | 6103 ± 433 | 8496 ± 321 | 201 ± 11 | 296 ± 24 | 29 ± 2 | 143 ± 11 | 2154 ± 450 | 2380 ± 178 |
| Heart | 3614 ± 200 | 5809 ± 265 | 94 ± 4 | 299 ± 11 | 6180 ± 374 | 9085 ± 582 | 221 ± 14 | 298 ± 16 | 34 ± 3 | 155 ± 11 | 1005 ± 114 | 2217 ± 201 |