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. 2017 Jul 24;7:6285. doi: 10.1038/s41598-017-06731-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pancreatic islets of patients with type 2 diabetes contain more CD45 + immune cells than islets of non-diabetic subjects. (a) Representative islet histology of type 2 diabetic (T2D) and non-diabetic (ND) subjects. Peri-islet and intra-islet CD45 + immune cell count (b and c, respectively) and distribution (d and e, respectively) in human pancreatic tissue sections of T2D and ND control subjects. Islet area (f) and islet-area-corrected average CD45 + immune cell count (g) in T2D and ND control subjects. (b–e) n = 17, 16 for T2D and ND subjects, respectively, (f,g) n = 14, 10 for T2D and ND subjects. n = 30–35 islets/subject were counted. ***P < 0.001. Statistical significance (P) was determined using the two-tailed Mann-Whitney U test. All error bars denote s.e.m.