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. 2017 Jul 24;7:6266. doi: 10.1038/s41598-017-06552-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The acute effects of puerarin on FST and EPMT. In FST, there was no significant effect on the immobility time in pretest (A) and test (B) duration among groups. Similar to FST (15 mg/kg, i.g), both drugs did not induce the anxiolytic-like effects in EPMT, as evidenced by that the percentage of the time (C)/entries (D) into open arms and total time (E)/entries (F) in arms among groups were not different. (n = 10 per group).