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. Author manuscript; available in PMC: 2017 Jul 25.
Published in final edited form as: Sci Signal. 2017 Mar 21;10(471):eaaj1549. doi: 10.1126/scisignal.aaj1549

Fig 5. SNI-induced gene expression patterns indicated common signal transduction pathways are affected in the mPFC, NAc and PAG and show robust overlap with genes previously implicated in anxio-depressive states and pain. (A).

Fig 5

Comparison of IPA derived canonical signaling pathways affected by gene expression patterns in mPFC, NAc, and PAG samples from SNI vs. sham. (B) Overlap of differentially expressed genes from present RNAseq study (mPFC, NAc, and PAG combined) to genes previously implicated in depression, anxiety, and pain, mostly from post-mortem human brain samples or mutant KO mouse behavioral studies.